The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.
Identifieur interne : 000147 ( an2020/Analysis ); précédent : 000146; suivant : 000148The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.
Auteurs : Hussin A. Rothan [États-Unis] ; Siddappa N. Byrareddy [États-Unis]Source :
- Journal of autoimmunity [ 1095-9157 ] ; 2020.
Abstract
Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. Person-to-person transmission of COVID-19 infection led to the isolation of patients that were subsequently administered a variety of treatments. Extensive measures to reduce person-to-person transmission of COVID-19 have been implemented to control the current outbreak. Special attention and efforts to protect or reduce transmission should be applied in susceptible populations including children, health care providers, and elderly people. In this review, we highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease.
DOI: 10.1016/j.jaut.2020.102433
PubMed: 32113704
Affiliations:
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Rothan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA. Electronic address: hrothan@gsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA</wicri:regionArea><wicri:noRegion>GA</wicri:noRegion></affiliation></author><author><name sortKey="Byrareddy, Siddappa N" sort="Byrareddy, Siddappa N" uniqKey="Byrareddy S" first="Siddappa N" last="Byrareddy">Siddappa N. Byrareddy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE, USA; Department of Genetics, Cell Biology and Anatomy, Omaha, NE, USA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, NE, USA. Electronic address: sid.byrareddy@unmc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE, USA; Department of Genetics, Cell Biology and Anatomy, Omaha, NE, USA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, NE</wicri:regionArea><wicri:noRegion>NE</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of autoimmunity</title><idno type="eISSN">1095-9157</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. Person-to-person transmission of COVID-19 infection led to the isolation of patients that were subsequently administered a variety of treatments. Extensive measures to reduce person-to-person transmission of COVID-19 have been implemented to control the current outbreak. Special attention and efforts to protect or reduce transmission should be applied in susceptible populations including children, health care providers, and elderly people. 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